A new study published in Science Digest and scheduled for publication in Cancer Epidemiology Biomarkers & Prevention next month concluded that reducing carbohydrate intake could reduce the risk of breast cancer recurrence in women whose tumor tissue is positive for the IGF-1 receptor. The researchers said “There is a growing body of research demonstrating associations between obesity, diabetes, and cancer risk. ” “There are similarities between the biological pathways that underlie all of these conditions, and there is some evidence to suggest that over-activation of the insulin/insulin-like growth factor axis, which increases the availability of IGF1 in the blood, may relate to a poor prognosis among breast cancer survivors. ” Because diet influences insulin activation, researchers wondered if diet could impact breast cancer prognosis based upon expression of the IGF1 receptor in the primary breast tumor tissue. Women studied were part of a larger study on Women’s Healthy Eating and Living (WHEL) carried out between 2001 and 2007. Researchers found an association between increased breast cancer recurrence in women with a primary breast cancer tumor that was positive for IGF1 receptor, consistent with previous studies. They also found that a decrease in carbohydrate intake was associated with decreased breast cancer recurrence in these women. More research is needed to validate these findings.
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