Holistic Health Show with Carl Helvie logoA new study published in the American Journal of Gastroenterology concluded that the rate of developing esophageal squamous cell carcinoma (ESCC) nearly doubles in those who smoke and drink compared to those who only smoke or drink. Authors stated “Our study suggests that not only do alcohol and tobacco play an important role in the development of esophageal cancer, the combination of their use markedly increases their potential as carcinogens.”

Researchers carried out a systematic search of the literature on multiple electronic data bases for population-based-case-controlled or cohort studies of ESCC that assessed the effect of tobacco and/or alcohol. To estimate the interaction of alcohol, and /or tobacco on esophageal cancer on a multiplicative scale a synergy factor was calculated from studies for the burden of esophageal cancer on those who smoked and/or drank. The researchers concluded “Our systematic review confirmed the expected exposure-dependent relationship of both alcohol and tobacco with the risk of ESCC. as alcohol use and tobacco use were both independent risk factors for the development of ESCC.”