Greater risk of breast cancer: A new study published in the Journal of the National Cancer Institute concluded that a high total and saturated fat intake are associated with a greater risk of estrogen receptor-and progesterone receptor-positive (ER+PR+) breast cancer and human epidermal growth factor 2 receptor- negative (HER2-) disease. Previous data on this association has been conflicting. In this study researchers prospectively analyzed data from over 10,000 breast cancer +patients with 11.5 years follow up. This data was taken from a larger cohort study of over 337,300 women living in 10 European countries, that created a heterogeneous cohort in terms of geography-related dietary fat intake patterns and molecular subtypes. These were seen as possible factors resulting in conflicting data from previous studies. Dietary questionnaire data was used with the sample. Results showed that high total and high saturated fat intake were associated with greater risk of ER+PR+breast cancer. High saturated fat intake was associated with greater risk of breast cancer, HER2-disease. Researchers concluded “a high-fat diet increases BC risk and, most conspicuously, that high saturated fat intake increases r=risk of receptor-positive disease, suggesting saturated fat involvement in the etiology of receptor-positive BC.”
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